Best Gaming Mouse with Thumb Rest 2021 – Buyer’s Guide

Accuracy and comfort are two important things that a high quality gaming mouse should possess. A gaming keyboard should be ergonomically designed because you’re going to use it for extended hours if you’re a hardcore gamer. When you’re playing games on PC that require accurate and rapid aiming, having a good quality gaming mouse with thumb rest that is comfortable to use is the perfect way to make sure you’re playing like a pro.

The best gaming mouse with thumb rest will ensure that your hand movements are tracked instantly and accurately. There are lots of gaming mice available on the market, but you must make an informed decision according to your requirements. If you need a high-end mouse that is perfect for particular gaming genres such as FPS or MOBA or any other, this comprehensive guide will help you find a good one.

Top-Rated Gaming Mouse with Thumb Rest

Things you MUST KNOW before choosing your Best Gaming Mouse with Thumb Rest

We have jotted down the list of the best gaming mice based on our preferences and likings. It isn’t necessary that our choices meet your needs, though they are very comprehensive but you need to look at some features discussed below. Following are the factors to look for in a gaming mouse with thumb rest:


Overall, a gaming mouse should be ergonomically designed; having a thumb rest adds to the comfort of the mouse. A good quality mouse should be able to customize its body according to your hand. Considering the overall design is imperative because it will play a big role in your overall experience. Traditional mice have a simple design while those that are more ergonomically designed have a bit of a learning curve because of the unique design.

Wired or Wireless

Wireless mice have become quiet famous because they add a clutter-free experience to the usage. However, there are some downsides too like the battery life is limited especially if it is equipped with RGB. If you are willing to go for a wireless, then go for one that has a battery life of 30 hours or more. Bluetooth is quiet useful if you want to switch to other devices but this comes with a latency cost too.

Optical or Laser

Optical and laser both sensors are of good quality but optical sensor offers a slightly better accuracy. One benefit of laser mice is that they work on a variety of surface types. If you want to buy an optical mouse, then go with one that is equipped with PixArt.


Do you like a simple traditional mouse with two buttons or one that is equipped with more features like side buttons or the central one? The choice of buttons will depend on your usage; if you play a lot of games, then it is better to have one that has more controls. Having buttons on the mouse depends on your personal preference.


Most of the high-end mice are equipped with mouse-control customization software that help you personalize your experience. This type of software allows you to control and customize the mouse such as recording macro commands, activate premade, create your own profiles, and make game-

specific profiles.

Our top picks for the Best Gaming Mouse with Thumb Rest

If you ever had pain or numbness in your fingers and wrist because of gaming for extended hours, you know it can affect your gameplay by far. A gaming mouse with thumb rest is very comfortable and can ease your pain that is caused by using the PC for a long period. The good thing is that there are plenty of options that are available when it comes to choosing a gaming mouse with thumb rest. Following are our top picks:

1. Logitech MX Master 2S- (Best overall)


  • Maximum operating distance: 33 ft
  • Connectivity: wireless
  • Buttons: 7
  • Interface: 2.4 GHz
  • Movement detection technology: laser
  • Movement resolution: 4000 dpi

Logitech MX Master 2S Review

The Logitech MX Master 2S is ergonomically designed and it provides a full-hand support to the user. The thumb rest promotes a better forearm posture and gives you a good input option for performing various computing tasks. It has an expansive thumb rest that molds to the palm and gives cushion to it. The Logitech gaming mouse is a very comfortable one and helps you play your favorite games for many hours.

The button layout of this gaming mouse is excellent and the software combination is superb too. It features a wireless battery life of 70 days which is quiet handy because you don’t need to charge it again and again. The mouse is designed for right-handed users and has a hand sculpted design that keeps the wrist in horizontal orientation. The laser sensor allows the device to track on any surface easily.


  • It provides a very comfortable grip.
  • It has a beautiful design.
  • The support software is excellent.
  • There are good scroll wheel and button options.
  • It features Bluetooth or 2.4 GHz options for pairing.


  • There is no storage compartment for the 2.4 GHz dongle.

2. Razer Basilisk Ultimate- (Best for FPS gaming)


  • Sensor: Razer Focus+ Optical
  • CPI: 20,000
  • IPS: 650 IPS
  • Acceleration: 50G
  • Interface: USB / 2.4 GHz wireless
  • Ergonomics: right handed palm and claw grip
  • Programmable buttons: 11

Razer Basilisk Ultimate Review

The Razer Basilisk Ultimate is a high-quality gaming mouse with thumb rest as it is equipped with semi-intelligent sensor packs. The sensor packs have a CPI rating of 20,000 and IPS rating of 650. The gaming mouse has a nice ergonomic design and a superb killer pointer. The good thing is that you can control the scroll resistance wheel because the sensor is made up of good quality materials that allow good control. The switches of this mouse are lightning-quick optical ones that are 3 times faster than mechanical actuation.

The Basilisk gaming mouse is one of the favorites when it comes to the First-Person Shooters. It has a sharp design at the front and a cool texture on the thumb rest. The mouse is meant for right-handed users and is equipped with lots of customizable buttons and 14 RGB zones. The ability to program each button is very handy and allows you to customize the mouse according to your needs. The mouse glides smoothly over any surface and can be used by any hand size.


  • The sensor is quick and accurate.
  • The software suite is quite intuitive.
  • It features fast charging and has a long battery life.
  • It is shaped perfectly for different grip types.


  • It is expensive
  • The optical switches lack the mechanical feel

3. Logitech G502 Hero


  • Max DPI: 16,000
  • Buttons: 11
  • Movement detection technology: optical
  • Interface: USB
  • Connectivity: Wired

Logitech G502 Hero Review

The Logitech Hero is one of the best gaming mice with thumb rest as it has a large layout with customizable features. The G502 is a well-designed mouse that is extremely comfortable to use and you can hold it for long periods. It is equipped with Logitech G Hub software that allow you to setup custom profile easily for all of your favorite games which you play the most. The mouse’s heft can also be adjusted using tunable weights that are easy to install.

Though the gaming mouse has been introduced some years ago, but it has been upgraded a lot until now. For example, the Proteus Spectrum update is a useful one and it provided the mouse with full RGB lighting. A more recent update has replaced the old sensor with an advanced and powerful higher DPI model. The mouse is also equipped with mechanical switch button tensioning that offers a crisp and clean click with quick click feedback.


  • It has a comfortable and intuitive design
  • The layout is smart
  • Buttons are big and easy to use
  • The software is very useful with lots of options


  • Might not be suitable for big-hand players with palm-grip usage.

4. Corsair Dark Core RGB Pro


  • Sensor type: Optical
  • Sensitivity: 18,000 DPI
  • Programmable buttons: 8
  • LED zones: 9 RGB zones
  • Connectivity: Bluetooth 4.0, Corsair Slipstream USB type-A dongle, removable USB type-A cable

Corsair Dark Core RGB Pro Review

The Corsair Dark Core RGB Pro is an all-rounder when it comes to gaming mouse with thumb rest. It features a multi-button mouse with a superb battery-life. The design is comfortable and fits in hands ergonomically. You can easily feel the pace present between the palm and the palm rest because it is large enough. There is a texturized finish over the palm rest and the thumb rest that give good grip and keeps your hand in place while you’re using it.

The Corsair gaming moue gives brilliant performance with blazing fast speeds. It is very powerful for and the 18,000 DPI is a big plus point for gaming. The button responses are accurate and quick and the remapping function is very useful. However, if you are on budget, we don’t recommend it as it is a bit expensive when it comes to gaming mice. The Corsair gaming mouse is also equipped with a reliable sensor along with easily accessible programmable buttons.


  • It features low latency.
  • It is equipped with very robust software.
  • It is very comfortable to use.
  • It has a clean layout.
  • It feature a good battery life.
  • It is equipped with a 8-button mart layout.


  • It is difficult to be used when wired

5. Corsair Ironclaw RGB- (Best for big hands)


  • Max DPI: 18,000
  • Programmable buttons: 5
  • Interface: Wireless
  • IPS: 450
  • Sensor: Pixart PMW3391

Corsair Ironclaw RGB Review

The Corsair Ironclaw, as the name suggests, is meant for big hands and features wide grips. It is one of the thickest gaming mice available as it measures around 3 inches at its widest point. The mouse is designed for right-handed users and has a palm-hugging type grip. The sensor of this mouse is named as Pixart PMW3391 which is equipped with a DPI of 18,000 and also has a highest IPS rating of 450. These are high-end specs which are meant for high-end gaming and multi-monitor setups.

The gaming mouse with thumb rest is heavy and thus it can get a bit difficult for the FPS gamers because of the button layout. The mouse feature amazing tracking which help deliver a smooth gaming performance. The mouse is an affordable one and its feature doesn’t fall short of its competitors in the market. The only thing to complain about is that it’s heavy and the middle button requires some effort to press.


  • It has a very comfortable design, especially for palm grips.
  • The wireless connectivity is great.
  • The button layout is intuitive.
  • Price point is impressive.
  • The optical sensor is very precise.


  • It is a bit heavy.
  • The middle mouse button is little stiff.

6. Logitech MX Master 3- (Best productive mouse)


  • DPI: 4,000
  • Sensor: Darkfield
  • Interface: USB/wireless
  • Programmable button: 6

Logitech MX Master 3 Review

The Logitech MX Master 3 is another high performing gaming mouse with thumb rest. It features a nice electromagnetic wheel and it also offers a Bluetooth connection or dongle. The mouse is very powerful and it allows you to share texts, images, and various files with 3 PCs at the same time. There are 6 button that you can program and customize your experience. The thumb rest is very comfortable and is good for long gaming sessions.

The best thing about this gaming mouse is that you have to put a very little effort to use it; this makes sure that you aren’t much tired if you use it for extended hours. The gaming mouse is packed with powerful features and has an ergonomic design overall. The mouse is lightly taller than others but since the shape is very comfortable, it is perfect for gamers.


  • It is equipped with a smooth and fast scroll wheel.
  • It allows you to control and share files, images, and text to up to 3 PC setups.
  • Sculpting is super-comfy.
  • The battery life is superb.
  • It features downloadable profiles for your favorite apps.


  • The DPI customization isn’t accurate.
  • Connectivity suffers when multiple devices are connected.

7. Corsair Nightsword RGB


  • Sensor: optical
  • DPI: 18,000
  • IPS: 250
  • Acceleration: 50G
  • Connectivity: Wired, USB 3.0
  • Buttons: 8
  • LED zones: 4 RGB zones

Corsair Nightsword RGB Review

The Corsair Nightsword RGB features a comfortable chassis and it feature a gorgeous thick black chassis. The mouse is equipped with 10 programmable buttons that allow you to set macros to all the buttons using the action tab. The gaming mouse is perfect for FPS and MOBA players. It is equipped with lots of adjustable weights that make the whole design more ergonomic.

There is a large thumb rest on the left along with 5 thumb buttons. The gaming mouse with thumb rest is designed for gamers with large hands. Though the mouse feels a bit cheap around the buttons, but overall layout is good and the mouse has a sturdy feel. The adjustable weights allow you to fine tune how you game and that is very handy. Overall the mouse is perfect for gamers with big hands.


  • The grips are very comfortable.
  • It helps improving gaming performance by far.
  • It features weight adjustments.
  • There are many RGB zones.
  • The buttons feel great.


  • The scroll wheel is a bit far.

8. Logitech G604 Lightspeed Wireless Gaming Mouse- (Best for Battle Royale players)


  • DPI: 16,000
  • Sensor: Logitech Hero 16k optical sensor
  • Acceleration: > 40G
  • Buttons: 15
  • Software: Logitech G hub

Logitech G604 Lightspeed Wireless Gaming Mouse Review

Logitech’s wireless gaming mouse is meant for MMO, MOBA, and battle Royale players. The gaming mouse is equipped with six thumb macros on the sides that are targeted to those who need to give multiple in-game commands or macros for gaming. It has a right-handed design and has a wide thumb rest on the side. The mouse is equipped with a metal hyper-scroll wheel that can also be tilted to left and right through programming.

The configuration software G Hub is amazing, it is very easy to use and allows you to reconfigure settings like DPI presets, assignment of inputs, scroll wheel tilt inputs, and creating macros. The mouse allows you to store up to five profiles and customize them according to your preference. The mouse feels good in the hand and you quickly get used to the ergonomic design.


  • There are plenty of buttons including the scroll wheel tilt inputs.
  • It comes at a reasonable price for a wireless mouse.
  • It features powerful 2.4 GHz wireless connection.
  • The Hero 16k sensor is excellent.


  • The mouse is a bit tall.
  • The base panel is slippery.

Frequently Asked Questions

Is wireless gaming mouse better?

Gaming mice are available in various sizes, models, and designs. Having a good quality gaming mouse can be a perfect addition to your gaming rig. Most of the gamers prefer wireless gaming mice because they are clutter free and easy to use as compared to the wired ones. They make the PC desk appear neat because there is no more mess of wires. So, it depends on your personal preference whether you want to go for the wireless or the wired gaming mouse.

What does a tilt-clock scroll on a gaming mouse do?

There is a middle mouse button and a standard scrolling present on a gaming mouse, and apart from these inputs there is a tilt-click scroll too. The tilt-click scroll wheel provides you with two additional mouse buttons that are the right and left tilt clicks. However, before buying a mouse you should go through the specifications to know whether this feature is present or not.

Why do all the clicks look like they are at the middle of the screen?

In some games, especially the FPS ones that lock the pointer of the mouse at the center of the screen, this can be the issue. Sometimes in FPS games, all the clicks might register in the center. But if you believe that this behavior is not desired or is unexpected, you can contactthe manufacturer.

Are Bluetooth mice different from the USB ones?

Wireless mice are either Bluetooth or USB, and they provide you with the flexibility to move them on various surfaces. There is a difference between a Bluetooth mouse and a USB one when it comes to their way of operating. A USB mouse uses a USB port that you can attach to your PC and then send commands, while the Bluetooth mouse can be used only in systems that consist of Bluetooth feature.

Are wireless mice compact?

Wireless mice should be compact so that the gamers play with ease without any issue. Most of the wireless mice are thus designed with a compact layout so that it is easy for the gamers. However, the compactness and overall ergonomics also depends on the manufacturers.

What are the different types of grips for a mouse?

The grip types of a mouse include palm grip, tip grip, and claw grip. A palm grip mouse is good for games that have a longer session time and are at a slower pace. A tip grip mouse is good for FPS games and a claw grip provides greater speed than palm grip where the fingers are aimed directly down towards the primary buttons.


The gaming mouse with thumb rest reviewed in this post are all of high quality and are designed to be used for various gaming genres including MOBA, MMA, FPS, RPG, and RTS. Software also plays an important role in improving the overall gaming experience. The software suite differ for various manufacturers and the best ones are those that are easy to learn.

The Logitech MX Master 2S is one of the best gaming mouse with thumb rest and is highly recommended if you’re looking for one. This is the mouse for you if you’re looking for plenty of buttons, good programmability options, and a beautiful design. Apart from this, the Razer Basilisk Ultimate is one of the most flexible and comfortable gaming mice available on the market.

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